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| Very High Shear microfluidising usually produces the smallest and most consistent particle sizes... |
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Microfluidising
Very high shear processing offers advantages over conventional techniques
• smaller and tighter particle size distributions
• a faster process
• no contamination with grinding media
• easy to clean and operate asceptically or sterile
• heat generation is controllable
• you can grind material that other techniques such as impact cannot
Laboratory
Our Microjet Systems are engineered specifically for pharmaceuticals, biotech and healthcare applications. They are suitable for fine dispersions, emulsions and for cell disruption. Operating at up to 25,000 psi or as low as 2000 psi, each Microjet processor is fitted with our unique diamond interaction chamber. Diamond provides superior wear characteristics, superior chemical resistance and unique heat transmission properties. The Microjet produces extremely high liquid velocities which give very high levels of shear resulting in very fine, tight particle size distributions and very small particles of exceptional consistency. The process is fully scaleable and can be made fully cGMP compliant for asceptic and sterile applications. Laboratory and pilot scale machines can be bespoke designed to fit isolators and laminar flow cabinets.
How Does It Work?
Microjet Technology uses the principle of liquids moving at very high velocity in Microfluidic channels. The same principle is used in conventional homogeniser but at a much lower velocity and therefore energy.
What Kind of Products Are Best Suited To This technology?
Where there is a need for small particle size, typically sub-micron combined with a uniform distribution, and contamination free. This is particularly relevant to pharmaceuticals, biotechnology [particularly cell disruption] and healthcare. Or where other methods have failed.
What Kind of Products Are Not Suited To This technology?
It is not suitable for bulk or commodity compounds, For example commodity pigments or paint production would not be cost effective, and traditional bead mills would be more appropriate. Food ingredients are usually best produced using standard homogenisers.
How Does It Compare With Traditional Homogenisers?
It often produces a smaller particle size and is more efficient.
What governs the final particle size?
The final particle size of an emulsion or dispersion is dependent on the energy applied and on the chemistry. The surfactants and electrical charge play a key role. The smaller the particle size, the larger the particles' surface area and the greater the role of electrical charge on the stability.
Is Smaller Particle Size Better?
Very often. If the mean size is smaller then drugs are more easily absorbed in or on the body. Formulations are generally more stable.
Does Higher Pressure Produce Smaller Particle Sizes?
Not always.
Pilot and Process
For scaling up and for electrically powered systems we work in conjunction with Stansted Fluid Power Limited who specialise in the advanced pump technology required for single and double intensifier systems suitable for pharmaceutical use.
Systems can be built with either standard homogeniser style valves or with fixed geometry diamond interaction chambers.
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